Episode 11: It's Toxic... It's LAST!

clinical pharmacology Apr 01, 2020


Episode Summary

In this episode of the APEX Live Anesthesia Podcast, we dive into local anesthetic systemic toxicity (LAST). If you administer any local anesthetic medications in your practice, you don't want to miss this episode! 


What You'll Learn

  • What is LAST?
  • What agents cause LAST?
  • What is the pathophysiology of LAST?
  • What are the signs and symptoms of a LAST event?
  • Are some patients more susceptible to LAST than others?
  • How you you manage a CNS toxicity and cardiac toxicity during a LAST event?


Resources Mentioned in the Episode


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Recommended Resources

  1. Neal JM. The American Society of Regional Anesthesia and Pain Medicine Checklist for Managing Local Anesthetic Systemic Toxicity: 2017 Version. Reg Anes Pain Med. 2018 Feb;43(2):150-153. 

  2. Local Anaesthetics

  3. Anand Swaminathan, "Local Anesthetic Systemic Toxicity (LAST)", REBEL EM blog, May 18, 2017. 

  4. Cao D et al. Intravenous lipid emulsion in the emergency department: a systematic review. J Emerg Med 2015; 48(3): 387-97.

  5. Weinberg G. Local anesthetic toxicity – Overview. Lipid Rescue Resuscitation: 20% lipid emulsion for rescue from drug toxicity. 

  6. El-Boghdadly, K, et al. Local Anesthetic Systemic Toxicity: Current Perspectives. Local Reg Anesth. 2018 Aug 8;11:35-44. 


Legal Disclaimer

APEX Anesthesia Review, LLC and APEX Live expressly disclaim any liability in connection with the use of any content in its podcasts, social media posts, and all other published content by any third party.

Podcast music by Eino Toivanen, kongano.com


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