Episode 16: Ketamine - The Swiss Army Knife of Anesthetic Drugs

clinical pharmacology Aug 01, 2020

Episode Summary

In this episode of the APEX Live Anesthesia Podcast, we are going to dive into the world of ketamine. We’ll review the little brother to PCP, and talk about all the situations where it can be useful…it really is the swiss army knife of anesthetic meds!

 

What You'll Learn

  • What is the pharmacology of ketamine?
  • What is an appropriate dose of ketamine?
  • What is the current evidence with ketamine’s use with increased intracranial pressure?
  • What is delayed sequence induction?
  • How is ketamine used for analgesia?

  

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Recommended Resources

  1. Aleksandrova LR, Phillips AG, Wang YT. Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism. J Psychiatry Neurosci. 2017;42(4):222-229. 

  2. Bar-Joseph G, Guilburd Y, Tamir A, Guilburd JN. Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension. J Neurosurg Pediatr. 2009;4(1):40-46.

  3. Ghojazadeh M, Sanaie S, Paknezhad SP, Faghih SS, Soleimanpour H. Using Ketamine and Propofol for Procedural Sedation of Adults in the Emergency Department: A Systematic Review and Meta-Analysis. Adv Pharm Bull. 2019;9(1):5-11.

  4. Hashimoto K. Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective. Psychiatry Clin Neurosci. 2019;73(10):613-627.

  5. Jankauskas V, Necyk C, Chue J, Chue P. A review of ketamine's role in ECT and non-ECT settings. Neuropsychiatr Dis Treat. 2018;14:1437-1450. Published 2018 Jun 6.

  6. Liriano F, Hatten C, Schwartz TL. Ketamine as treatment for post-traumatic stress disorder: a review. Drugs Context. 2019;8:212305. Published 2019 Apr 8.

  7. Merelman AH, Perlmutter MC, Strayer RJ. Alternatives to Rapid Sequence Intubation: Contemporary Airway Management with Ketamine. West J Emerg Med. 2019;20(3):466-471.

  8. Nagelhout JJ. Intravenous Induction Agents. In: Nagelhout JJ, Elisha S, eds. Nurse anesthesia, 6th ed. St. Louis, Missouri: Elsevier, 2018:93-109.

  9. Porter SB. Perioperative ketamine for acute analgesia and beyond. Rom J Anaesth Intensive Care. 2019;26(1):67-73.

 

Legal Disclaimer

APEX Anesthesia Review, LLC and APEX Live expressly disclaim any liability in connection with the use of any content in its podcasts, social media posts, and all other published content by any third party.

Podcast music by Eino Toivanen, kongano.com

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