In this episode of the APEX Live Anesthesia Podcast, we’ll talk about the coagulation cascade and how we can reduce perioperative bleeding with antifibrinolytic medications. Next, we’ll analyze the current evidence, discuss best practices, and drop a few knowledge bombs to ensure your practice is up-to-date.
We know that you miss going to live events right now - and we do too!
That's why we decided to pull out all the stops on this year's APEX Live Virtual CPC Review Course.
By attending virtually, there are no long flights, no rental cars, and no forgetting things at home. You can even show up in your PJs if you'd like!
If you want an engaging review for the NBCRNA CPC Exam, with the flexibility to attend virtually, then you came to the right place.
We’re here to help you improve your practice, and we want to make sure our content is relevant for you.
Brenner, A., Afolabi, A., Ahmad, S.M. et al. Tranexamic acid for acute gastrointestinal bleeding (the HALT-IT trial): statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. Trials 20, 467 (2019).
Gayet-Ageron A, Prieto-Merino D, Ker K, et al. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 38 bleeding patients. Lancet. 2018;391(10116):125-132.
Perel P, Al-Shahi S, Kawahara T, et al. CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury–a nested randomized, placebo-controlled trial. Health Technol Assess. 2012;16(13):iii-xii, 1-54.
Poeram, J., et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United states: Retrospective analysis of effectiveness and safety. BJM. Aug 2014;349:g4829.
Roberts I, Shakur H, Coats T, et al. The CRASH-2 trial: a randomized controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013;17(10):1-79.
Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomized, placebo-controlled trial. Lancet. 2010;376(9734):23-32.
Sprigg N, Flaherty K, Appleton J, et al. Tranexamic acid for hyperacute primary Intra-Cerebral Haemorrhage (TICH-2): an international randomized, placebo-controlled, phase 3 superiority trial. Lancet. 2018;391(10135):2107-2115.
The CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomized, placebo-controlled trial. Lancet. October 14, 2019.
WOMAN trial collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017;389(10084):2105-2116.
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Podcast music by Eino Toivanen, kongano.com