Episode 5: Anaphylaxis
Nov 01, 2019
In this episode of the APEX Live Anesthesia Podcast, we discuss a critical event that you'll likely manage at some point in your career. Anaphylaxis is a severe life threatening generalized or hypersensitivity reaction. We'll discuss the incidence, triggering agents, mechanism of action, signs and symptoms, and management of this crisis.
What You'll Learn
- How often does anaphylaxis occur in the general population and during anesthesia?
- What are the different types of hypersensitivity reactions?
- Which agents are known to cause anaphylaxis?
- What are the cardiovascular effects and other signs and symptoms associated with anaphylaxis?
- What is the most current evidence regarding the management of anaphylaxis?
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Ring J, et al. Guideline for acute therapy and management of anaphylaxis. Allegro J Int. 2014;23(3): 96-112.
Reber LL, et al. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. 2017;140:335-48.
Ebo DG, et al. Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: A narrative review. British Journal of Anesthesia. 2019;123(1):e38-e49.
World Allergy Organization. Epinephrine: The drug of choice for anaphylaxis-A statement of the World Allergy Organization. World Allergy Organ J. 2008; Jul1(Suppl 2): S18-S26.
Miyazaki Y, et al. Incidence of anaphylaxis associated with Sugammadex. Anesth Analg.2018;126(5):1505-08.
Dewachter P, et al. Anaphylaxis and anesthesia: controversies and new insights. Anesthesiology. 2009;111:1141-50.
Sadleir PHM, et al. Anaphylaxis to neuromuscular blocking drugs: Incidence and cross reactivity in Western Australia from 2002-2011. British Journal of Anaesthesia. 2013;110(6):981-87.
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Podcast music by Eino Toivanen, kongano.com