Episode 5: Anaphylaxis

Episode Summary

In this episode of the APEX Live Anesthesia Podcast, we discuss a critical event that you'll likely manage at some point in your career. Anaphylaxis is a severe life threatening generalized or hypersensitivity reaction. We'll discuss the incidence, triggering agents, mechanism of action, signs and symptoms, and management of this crisis.


What You'll Learn

  • How often does anaphylaxis occur in the general population and during anesthesia?
  • What are the different types of hypersensitivity reactions?
  • Which agents are known to cause anaphylaxis?
  • What are the cardiovascular effects and other signs and symptoms associated with anaphylaxis?
  • What is the most current evidence regarding the management of anaphylaxis?


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Recommended Resources

  1. Ring J, et al. Guideline for acute therapy and management of anaphylaxis. Allegro J Int. 2014;23(3): 96-112. 

  2. Reber LL, et al. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. 2017;140:335-48.

  3. Ebo DG, et al. Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: A narrative review. British Journal of Anesthesia. 2019;123(1):e38-e49.

  4. World Allergy Organization. Epinephrine: The drug of choice for anaphylaxis-A statement of the World Allergy Organization. World Allergy Organ J. 2008; Jul1(Suppl 2): S18-S26.

  5. Miyazaki Y, et al. Incidence of anaphylaxis associated with Sugammadex. Anesth Analg.2018;126(5):1505-08.

  6. Dewachter P, et al. Anaphylaxis and anesthesia: controversies and new insights. Anesthesiology. 2009;111:1141-50.

  7. Sadleir PHM, et al. Anaphylaxis to neuromuscular blocking drugs: Incidence and cross reactivity in Western Australia from 2002-2011. British Journal of Anaesthesia. 2013;110(6):981-87. 


Legal Disclaimer

APEX Anesthesia Review, LLC and APEX Live expressly disclaim any liability in connection with the use of any content in its podcasts, social media posts, and all other published content by any third party.

Podcast music by Eino Toivanen, kongano.com


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