Episode 7: To Laugh Or Not To Laugh - Truths About Nitrous Oxide

clinical pharmacology Dec 15, 2019

Episode Summary

Surprise! In this mid-month bonus episode of the APEX Live Anesthesia Podcast, we'll talk about our friend and foe nitrous oxide. You know…that anesthetic gas that is great and horrible all at the same time. We'll briefly review its pharmacologic properties and then consider the current thinking and controversies about its clinical use.


What You'll Learn

  • What are the basic properties of nitrous oxide?
  • Why would nitrous oxide be a desirable part of an anesthetic?
  • What are the undesirable aspects of using nitrous oxide as part of an anesthetic?


Want to Attend an APEX Live Event?

Get everything you need to pass the CPC Assessment while having plenty of time to enjoy your vacation.

Click here to learn more.


Comments & Suggestions

We’re here to help you improve your practice, and we want to make sure our content is relevant for you.

Click here to share your thoughts.


Recommended Resources

  1. The European Task Force on the use of nitrous oxide in clinical anaesthetic practice. The current place of nitrous oxide in clinical practice. EJA. 2015:32;8: 517-520.

  2. Ishizawa Y. General anesthetic gasses and the global environment. Anes & Analg. 2011:112;1: 213-216. 

  3. Muret J, et al. Environmental impacts of nitrous oxide: no laughing matter! Comment on Br J Anaesth 2019:122: 587-604. 

  4. Nogueira FR, et al. Comparison of DNA damage and oxidative stress in patient’s anesthetized with Desflurane associated or not with nitrous oxide: A prospective randomized clinical trial. Anesth Analg. 2018:126(4): 1198-1205.

  5. Mraovic B. Nitrous oxide added at the end of isoflurane anesthesia hastens early recovery without increasing the risk for postoperative nausea and vomiting: a randomized controlled trial. Canadian Journal of Anesthesia. 2018:65(2): 162-169.

  6. Myles PS, et al. The safety of addition of nitrous oxide to general anaesthesia in at risk patients having major non-cardiac surgery (ENIGMA-II): a randomized, single blind trial. Lancet. 2014:(384): 1446-1454.

  7. Schallner N, et al. The perioperative use of nitrous oxide: renaissance of an old gas of funeral of an ancient relic? Current Opinion in Anesthesiology. 2013:26(3): 354-360.

  8. Zdravka Z, et al. Update on nitrous oxide and its use in anesthesia practice. Clin Anesthesiology. 2018:32(2): 113-123.


Legal Disclaimer

APEX Anesthesia Review, LLC and APEX Live expressly disclaim any liability in connection with the use of any content in its podcasts, social media posts, and all other published content by any third party.

Podcast music by Eino Toivanen, kongano.com


50% Complete

Two Step

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.