Surprise! In this mid-month bonus episode of the APEX Live Anesthesia Podcast, we'll talk about our friend and foe nitrous oxide. You know…that anesthetic gas that is great and horrible all at the same time. We'll briefly review its pharmacologic properties and then consider the current thinking and controversies about its clinical use.
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Nogueira FR, et al. Comparison of DNA damage and oxidative stress in patient’s anesthetized with Desflurane associated or not with nitrous oxide: A prospective randomized clinical trial. Anesth Analg. 2018:126(4): 1198-1205.
Mraovic B. Nitrous oxide added at the end of isoflurane anesthesia hastens early recovery without increasing the risk for postoperative nausea and vomiting: a randomized controlled trial. Canadian Journal of Anesthesia. 2018:65(2): 162-169.
Myles PS, et al. The safety of addition of nitrous oxide to general anaesthesia in at risk patients having major non-cardiac surgery (ENIGMA-II): a randomized, single blind trial. Lancet. 2014:(384): 1446-1454.
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Podcast music by Eino Toivanen, kongano.com